Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Recent advances in cellular models for discovering prion disease therapeutics

Journal: 

Expert Opinion on Drug Discovery

Date: 

17 September, 2022
2022 Sep;17(9):985-996. doi: 10.1080/17460441.2022.2113773. Epub 2022 Aug 24

Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance

Journal: 

Journal of medicinal chemistry

Date: 

14 July, 2022
J Med Chem 2022 Jul 14;65(13):8998-9010. doi: 10.1021/acs.jmedchem.2c00205. Epub 2022 Jun 30.

Serpin Signatures in Prion and Alzheimer's Diseases

Journal: 

Molecular Neurobiology

Date: 

13 April, 2022
Mol Neurobiology. 2022 Apr 13. doi: 10.1007/s12035-022-02817-3. Online ahead of print.

PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt-Jakob Disease

Journal: 

Frontiers in Aging Neuroscience

Date: 

25 March, 2022

Front Aging Neurosci. 2022 Mar 25;14:848991. doi: 10.3389/fnagi.2022.848991. eCollection 2022.

Therapeutic strategies for identifying small molecules against prion diseases

Journal: 

Cell and Tissue Research

Date: 

6 January, 2022

Cell Tissue Res. 2022 Jan 6. doi: 10.1007/s00441-021-03573-x.

Expression pattern of Perilipins in human brain during aging and in Alzheimer's Disease

Journal: 

Neuropathology Applied Neurobiology

Date: 

27 July, 2021

Neuropathol Appl Neurobiol. 2021 Jul 27.doi: 10.1111/nan.12756. Online ahead of print.

Astrocytes-derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein

Journal: 

Journal of Extracellular Vescicles

Date: 

12 July, 2021

J Extracell Vesicles. 2021 Jul;10(9):e12114. doi: 10.1002/jev2.12114. Epub 2021 Jul 12.

Tackling prion diseases: a review of the patent landscape

Journal: 

Expert Opinion on Therapeutic Patents

Date: 

17 June, 2021

Expert Opin Ther Pat. 2021 Jun 17. doi: 10.1080/13543776.2021.1945033

Site-specific analysis of N-glycans from different sheep prion strains

Journal: 

Plos Pathogens

Date: 

18 February, 2021
PLoS Pathog. 2021 Feb 18;17(2):e1009232.doi: 10.1371/journal.ppat.1009232. eCollection 2021 Feb

Novel Regulators of PrP C Expression as Potential Therapeutic Targets in Prion Diseases

Journal: 

Expert Opinion on Therapeutic Targets

Date: 

7 July, 2020

Expert Opin Ther Targets. 2020 Jul 7;1-18. doi: 10.1080/14728222.2020.1782384.

In Silico/in Vitro Screening and Hit Evaluation Identified New Phenothiazine Anti-Prion Derivati

Journal: 

European Journal of Medicinal Chemistry

Date: 

8 April, 2020

Eur J Med Chem. 2020 Apr 8;196:112295. doi: 10.1016/j.ejmech.2020.112295.

How would defining Parkinson's as a prion disease impact the search of a cure?

Journal: 

Expert Review of Neurotherapeutics

Date: 

7 April, 2020

Expert Rev Neurother. 2020 Apr 7. doi: 10.1080/14737175.2020.1753504

NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation

Journal: 

Cellular and Molecular Neurobiology

Date: 

1 April, 2020

Cell Mol Neurobiol. 2020 Apr 1. doi: 10.1007/s10571-020-00834-1.

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