Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

Journal: 

Journal of Biological Chemistry

Date: 

12 February, 2019

J Biol Chem. 2019 Feb 12. pii: jbc.RA118.001907. doi: 10.1074/jbc.RA118.001907. [Epub ahead of print]

Copper Binding Regulates Cellular Prion Protein Function

Journal: 

Molecular Neurobiology

Date: 

7 February, 2019

Mol Neurobiol. 2019 Feb 7. doi: 10.1007/s12035-019-1510-9. [Epub ahead of print]

Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases

Journal: 

Molecular Neurobiology

Date: 

1 February, 2019

Mol Neurobiol. 2019 Feb 1. doi: 10.1007/s12035-019-1505-6.

Brain aging: A Ianus-faced player between health and neurodegeneration

Journal: 

Journal of Neuroscience Research

Date: 

11 January, 2019

J Neurosci Res. 2019 Jan 11. doi: 10.1002/jnr.24379.

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene

Journal: 

Acta Neuropathologica Communications

Date: 

3 January, 2019

Acta Neuropathol Commun. 2019 Jan 3;7(1):1. doi: 10.1186/s40478-018-0656-4.

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

Journal: 

Journal of Medicinal Chemistry

Date: 

24 August, 2018

J Med Chem. 2018 Sep 13;61(17):7640-7656. doi: 10.1021/acs.jmedchem.8b00610. Epub 2018 Aug 24.

Synthetic Prion Selection and Adaptation

Journal: 

Molecular Neurobiology

Date: 

3 August, 2018

Mol Neurobiol. 2018 Aug 3. doi: 10.1007/s12035-018-1279-2. [Epub ahead of print]

Conformational properties of intrinsically disordered proteins bound to the surface of silica nanoparticles

Journal: 

Biochimica et Biophysica Acta

Date: 

2 April, 2018

Biochim Biophys Acta. 2018 Apr 2. pii: S0304-4165(18)30088-6. doi: 10.1016/j.bbagen.2018.03.026.

Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases

Journal: 

Prion

Date: 

4 March, 2018

Prion. 2018 Mar 4;12(2):127-137. doi: 10.1080/19336896.2018.1464367. Epub 2018 May 18.

Hemoglobin mRNA Changes in the Frontal Cortex of Patients with Neurodegenerative Diseases

Journal: 

Frontiers Neuroscience

Date: 

22 January, 2018

Front Neurosci. 2018 Jan 22;12:8. doi: 10.3389/fnins.2018.00008. eCollection 2018.

The Role Of The Prion Protein In The Internalization Of α-Synuclein Amyloids

Journal: 

Prion

Date: 

8 January, 2018

Prion. 2018 Jan 8:0. doi: 10.1080/19336896.2017.1423186. [Epub ahead of print]

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.

Journal: 

Acta Neuropathologica

Date: 

4 January, 2018

Acta Neuropathol. 2018 Jan 4. doi: 10.1007/s00401-017-1803-x. [Epub ahead of print]

The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein

Journal: 

Plos One

Date: 

21 November, 2017

PLoS One. 2017 Nov 21;12(11):e0188308. doi: 10.1371/journal.pone.0188308. eCollection 2017.

Differential overexpression of SERPINA3 in human prion diseases

Journal: 

Scientific Reports

Date: 

15 November, 2017

Sci Rep. 2017 Nov 15;7(1):15637. doi: 10.1038/s41598-017-15778-8.

Elucidating the function of the prion protein

Journal: 

Plos Pathogens

Date: 

31 August, 2017

PLos Pathog. 2017 Aug 31;13(8):e1006458. doi: 10.1371/journal.ppat.1006458. eCollection 2017 Aug.

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

Journal: 

Scientific Reports

Date: 

30 August, 2017

Sci Rep. 2017 Aug 30;7(1):10050. doi: 10.1038/s41598-017-10236-x

Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia

Journal: 

Scientific Reports

Date: 

7 April, 2017

Sci Rep. 2017 Apr 7;7:46269. doi: 10.1038/srep46269

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases

Journal: 

European Journal of Medicinal Chemistry

Date: 

1 November, 2016

Eur J Med Chem. 2016 Nov 1. pii: S0223-5234(16)30935-7. doi: 10.1016/j.ejmech.2016.10.064. [Epub ahead of print]

Characterization of prion protein function by focal neurite stimulation

Journal: 

Journal of Cell Science

Date: 

15 October, 2016

J Cell Sci. 2016 Oct 15;129(20):3878-3891. Epub 2016 Sep 2.

 

The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain

Journal: 

Journal of Biological Chemistry

Date: 

14 October, 2016

J Biol Chem. 2016 Oct 14;291(42):21857-21868. Epub 2016 Aug 17.

In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution

Journal: 

Frontiers in Neuroscience

Date: 

27 September, 2016

Front Neurosci. 2016 Sep 27;10:437. eCollection 2016.

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

Journal: 

Analytical Chemistry

Date: 

6 September, 2016

Anal Chem. 2016 Sep 6;88(17):8468-75. doi: 10.1021/acs.analchem.6b00731. Epub 2016 Aug 12.

The Priority position paper: Protecting Europe's food chain from prions

Journal: 

Prion

Date: 

3 May, 2016

Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801.

Whole Blood gene expression profiling in preclinical and clinical cattle infected with atypical bovine spongiform encephalopathy

Journal: 

PLoS One

Date: 

13 April, 2016

PLoS One. 2016 Apr 13;11(4):e0153425. doi: 10.1371/journal.pone.0153425. eCollection 2016.

A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers

Journal: 

Biotechniques

Date: 

1 January, 2016

Biotechniques. 2016 Jan 1;60(1):35-41. doi: 10.2144/000114371. eCollection 2016.

Synthetic prions with novel strain-specified properties.

Journal: 

PLOS Pathogen

Date: 

31 December, 2015

PLoS Pathog. 2015 Dec 31;11(12):e1005354. doi: 10.1371/journal.ppat.1005354. eCollection 2015.

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.

Journal: 

Scientific Reports

Date: 

20 October, 2015

Sci Rep. 2015 Oct 20;5:15253. doi: 10.1038/srep15253.

Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains

Journal: 

Scientific Reports

Date: 

9 July, 2015

Sci Rep. 2015 Jul 9;5:11971. doi: 10.1038/srep11971.

Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c)

Journal: 

PeerJ

Date: 

19 March, 2015

PeerJ. 2015 Mar 19;3:e811. doi: 10.7717/peerj.811. eCollection 2015.

New insights into structural determinants of prion protein folding and stability

Journal: 

Prion

Date: 

4 March, 2015

Prion. 2015 Mar 4;9(2):119-24. doi: 10.1080/19336896.2015.1022023.

Pages

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