Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models

Journal: 

European Journal of Medicinal Chemistry

Date: 

5 January, 2023
2023 Jan 5;245(Pt 1):114923. doi: 10.1016/j.ejmech.2022.114923. Epub 2022 Nov 15.

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins

Journal: 

Prion

Date: 

3 January, 2023
2023 Dec;17(1):1-6. doi: 10.1080/19336896.2022.2163835.

Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein

Journal: 

Cell Death & Disease

Date: 

16 December, 2022
2022 Dec 16;13(12):1048. doi: 10.1038/s41419-022-05489-y.

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease

Journal: 

ACS Chemical Neuroscience

Date: 

7 December, 2022
2022 Dec 7;13(23):3314-3329. doi: 10.1021/acschemneuro.2c00357. Epub 2022 Nov 29.

Gerstmann-Sträussler-Scheinker Disease with F198S Mutation Induces Independent Tau and Prion Protein Pathologies in Bank Voles

Journal: 

Biomolecules

Date: 

21 October, 2022
2022 Oct 21;12(10):1537. doi: 10.3390/biom12101537.

Recent advances in cellular models for discovering prion disease therapeutics

Journal: 

Expert Opinion on Drug Discovery

Date: 

17 September, 2022
2022 Sep;17(9):985-996. doi: 10.1080/17460441.2022.2113773. Epub 2022 Aug 24

Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Journal: 

Biology (Basel)

Date: 

16 September, 2022
2022 Sep 16;11(9):1358. doi: 10.3390/biology11091358

Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein

Journal: 

Chemical Science

Date: 

5 August, 2022
2022 Aug 5;13(35):10406-10427. doi: 10.1039/d2sc00345g. eCollection 2022 Sep 14.

Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance

Journal: 

Journal of medicinal chemistry

Date: 

14 July, 2022
J Med Chem 2022 Jul 14;65(13):8998-9010. doi: 10.1021/acs.jmedchem.2c00205. Epub 2022 Jun 30.

Serpin Signatures in Prion and Alzheimer's Diseases

Journal: 

Molecular Neurobiology

Date: 

13 April, 2022
Mol Neurobiology. 2022 Apr 13. doi: 10.1007/s12035-022-02817-3. Online ahead of print.

PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt-Jakob Disease

Journal: 

Frontiers in Aging Neuroscience

Date: 

25 March, 2022

Front Aging Neurosci. 2022 Mar 25;14:848991. doi: 10.3389/fnagi.2022.848991. eCollection 2022.

The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures

Journal: 

Molecular Neurobiology

Date: 

9 January, 2022

Mol Neurobiol. 2022 Jan 9. doi: 10.1007/s12035-021-02666-6

Therapeutic strategies for identifying small molecules against prion diseases

Journal: 

Cell and Tissue Research

Date: 

6 January, 2022

Cell Tissue Res. 2022 Jan 6. doi: 10.1007/s00441-021-03573-x.

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

Journal: 

Cells

Date: 

28 December, 2021
Cells. 2021 Dec 28;11(1):87. doi: 10.3390/cells11010087.

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

Journal: 

Molecular Neurodegeneration

Date: 

11 December, 2021

Mol Neurodegener. 2021 Dec 11;16(1):82.doi: 10.1186/s13024-021-00491-y.

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

Journal: 

Viruses

Date: 

17 August, 2021

Viruses. 2021 Aug 17;13(8):1625. doi: 10.3390/v13081625.

Expression pattern of Perilipins in human brain during aging and in Alzheimer's Disease

Journal: 

Neuropathology Applied Neurobiology

Date: 

27 July, 2021

Neuropathol Appl Neurobiol. 2021 Jul 27.doi: 10.1111/nan.12756. Online ahead of print.

Astrocytes-derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein

Journal: 

Journal of Extracellular Vescicles

Date: 

12 July, 2021

J Extracell Vesicles. 2021 Jul;10(9):e12114. doi: 10.1002/jev2.12114. Epub 2021 Jul 12.

Tackling prion diseases: a review of the patent landscape

Journal: 

Expert Opinion on Therapeutic Patents

Date: 

17 June, 2021

Expert Opin Ther Pat. 2021 Jun 17. doi: 10.1080/13543776.2021.1945033

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

Journal: 

Antioxidants

Date: 

1 June, 2021

Antioxidants (Basel). 2021 Jun 1;10(6):893. doi: 10.3390/antiox10060893.

PMCA generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

Journal: 

Elife

Date: 

14 April, 2021

Elife. 2021 Apr 14;10:e65311.doi: 10.7554/eLife.65311.

Site-specific analysis of N-glycans from different sheep prion strains

Journal: 

Plos Pathogens

Date: 

18 February, 2021
PLoS Pathog. 2021 Feb 18;17(2):e1009232.doi: 10.1371/journal.ppat.1009232. eCollection 2021 Feb

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases

Journal: 

Prion

Date: 

19 December, 2020
Prion 2020 Dec;14(1):257-270.doi: 10.1080/19336896.2020.1854034.

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

Journal: 

Brain Communications

Date: 

14 September, 2020

Brain Commun. 2020 Sep 14;2(2):fcaa142. doi: 10.1093/braincomms/fcaa142. eCollection 2020.

Novel Regulators of PrP C Expression as Potential Therapeutic Targets in Prion Diseases

Journal: 

Expert Opinion on Therapeutic Targets

Date: 

7 July, 2020

Expert Opin Ther Targets. 2020 Jul 7;1-18. doi: 10.1080/14728222.2020.1782384.

The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells

Journal: 

Journal of Neurochemistry

Date: 

11 May, 2020

J Neurochem. 2020 May 11. doi: 10.1111/jnc.15040.

Chronic alpha-synuclein accumulation in rat hippocampus induces Lewy Bodies formation and specific cognitive impairments

Journal: 

eNeuro

Date: 

11 May, 2020

eNeuro. 2020 May 11. pii: ENEURO.0009-20.2020. doi: 10.1523/ENEURO.0009-20.2020

In Silico/in Vitro Screening and Hit Evaluation Identified New Phenothiazine Anti-Prion Derivati

Journal: 

European Journal of Medicinal Chemistry

Date: 

8 April, 2020

Eur J Med Chem. 2020 Apr 8;196:112295. doi: 10.1016/j.ejmech.2020.112295.

How would defining Parkinson's as a prion disease impact the search of a cure?

Journal: 

Expert Review of Neurotherapeutics

Date: 

7 April, 2020

Expert Rev Neurother. 2020 Apr 7. doi: 10.1080/14737175.2020.1753504

NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation

Journal: 

Cellular and Molecular Neurobiology

Date: 

1 April, 2020

Cell Mol Neurobiol. 2020 Apr 1. doi: 10.1007/s10571-020-00834-1.

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