Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease

Journal: 

ACS Omega

Date: 

15 November, 2019

ACS Omega. 2019 Nov 15;4(22):19913-19924. doi: 10.1021/acsomega.9b02824. eCollection 2019 Nov 26.

α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies

Journal: 

Annals of Clinica and Translational Neurology

Date: 

10 October, 2019

Ann Clin Transl Neurol. 2019 Oct;6(10):2120-2126. doi: 10.1002/acn3.50897. Epub 2019 Oct 10.

Structural Consequences of Copper Binding to the Prion Protein

Journal: 

Cells

Date: 

25 July, 2019

Cells. 2019 Jul 25;8(8). pii: E770. doi: 10.3390/cells8080770.

Novel screening approaches for human prion diseases drug discovery.

Journal: 

Expert Opinion on Drug Discovery

Date: 

4 July, 2019

Expert Opin Drug Discov. 2019 Jul 4:1-11. doi: 10.1080/17460441.2019.1637851. [Epub ahead of print]

Prion Efficiently Replicates in α-Synuclein Knockout Mice

Journal: 

Molecular Neurobiology

Date: 

30 April, 2019

Mol Neurobiol. 2019 Apr 30. doi: 10.1007/s12035-019-1602-6. [Epub ahead of print]

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

Journal: 

Journal of Biological Chemistry

Date: 

12 February, 2019

J Biol Chem. 2019 Feb 12. pii: jbc.RA118.001907. doi: 10.1074/jbc.RA118.001907. [Epub ahead of print]

Copper Binding Regulates Cellular Prion Protein Function

Journal: 

Molecular Neurobiology

Date: 

7 February, 2019

Mol Neurobiol. 2019 Feb 7. doi: 10.1007/s12035-019-1510-9. [Epub ahead of print]

Brain aging: A Ianus-faced player between health and neurodegeneration

Journal: 

Journal of Neuroscience Research

Date: 

11 January, 2019

J Neurosci Res. 2019 Jan 11. doi: 10.1002/jnr.24379.

Synthetic Prion Selection and Adaptation

Journal: 

Molecular Neurobiology

Date: 

3 August, 2018

Mol Neurobiol. 2018 Aug 3. doi: 10.1007/s12035-018-1279-2. [Epub ahead of print]

Conformational properties of intrinsically disordered proteins bound to the surface of silica nanoparticles

Journal: 

Biochimica et Biophysica Acta (BBA) - General Subjects

Date: 

11 July, 2018

Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1556-1564. doi: 10.1016/j.bbagen.2018.03.026. Epub 2018 Apr 2.

Conformational properties of intrinsically disordered proteins bound to the surface of silica nanoparticles

Journal: 

Biochimica et Biophysica Acta

Date: 

2 April, 2018

Biochim Biophys Acta. 2018 Apr 2. pii: S0304-4165(18)30088-6. doi: 10.1016/j.bbagen.2018.03.026.

Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases

Journal: 

Prion

Date: 

4 March, 2018

Prion. 2018 Mar 4;12(2):127-137. doi: 10.1080/19336896.2018.1464367. Epub 2018 May 18.

Hemoglobin mRNA Changes in the Frontal Cortex of Patients with Neurodegenerative Diseases

Journal: 

Frontiers Neuroscience

Date: 

22 January, 2018

Front Neurosci. 2018 Jan 22;12:8. doi: 10.3389/fnins.2018.00008. eCollection 2018.

The Role Of The Prion Protein In The Internalization Of α-Synuclein Amyloids

Journal: 

Prion

Date: 

8 January, 2018

Prion. 2018 Jan 8:0. doi: 10.1080/19336896.2017.1423186. [Epub ahead of print]

Differential overexpression of SERPINA3 in human prion diseases

Journal: 

Scientific Reports

Date: 

15 November, 2017

Sci Rep. 2017 Nov 15;7(1):15637. doi: 10.1038/s41598-017-15778-8.

Elucidating the function of the prion protein

Journal: 

Plos Pathogens

Date: 

31 August, 2017

PLos Pathog. 2017 Aug 31;13(8):e1006458. doi: 10.1371/journal.ppat.1006458. eCollection 2017 Aug.

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases

Journal: 

European Journal of Medicinal Chemistry

Date: 

1 November, 2016

Eur J Med Chem. 2016 Nov 1. pii: S0223-5234(16)30935-7. doi: 10.1016/j.ejmech.2016.10.064. [Epub ahead of print]

Characterization of prion protein function by focal neurite stimulation

Journal: 

Journal of Cell Science

Date: 

15 October, 2016

J Cell Sci. 2016 Oct 15;129(20):3878-3891. Epub 2016 Sep 2.

 

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