Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Serpin Signatures in Prion and Alzheimer's Diseases

Journal: 

Molecular Neurobiology

Date: 

13 April, 2022
Mol Neurobiology. 2022 Apr 13. doi: 10.1007/s12035-022-02817-3. Online ahead of print.

PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt-Jakob Disease

Journal: 

Frontiers in Aging Neuroscience

Date: 

25 March, 2022

Front Aging Neurosci. 2022 Mar 25;14:848991. doi: 10.3389/fnagi.2022.848991. eCollection 2022.

The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures

Journal: 

Molecular Neurobiology

Date: 

9 January, 2022

Mol Neurobiol. 2022 Jan 9. doi: 10.1007/s12035-021-02666-6

Therapeutic strategies for identifying small molecules against prion diseases

Journal: 

Cell and Tissue Research

Date: 

6 January, 2022

Cell Tissue Res. 2022 Jan 6. doi: 10.1007/s00441-021-03573-x.

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

Journal: 

Cells

Date: 

28 December, 2021
Cells. 2021 Dec 28;11(1):87. doi: 10.3390/cells11010087.

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

Journal: 

Molecular Neurodegeneration

Date: 

11 December, 2021

Mol Neurodegener. 2021 Dec 11;16(1):82.doi: 10.1186/s13024-021-00491-y.

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

Journal: 

Viruses

Date: 

17 August, 2021

Viruses. 2021 Aug 17;13(8):1625. doi: 10.3390/v13081625.

Expression pattern of Perilipins in human brain during aging and in Alzheimer's Disease

Journal: 

Neuropathology Applied Neurobiology

Date: 

27 July, 2021

Neuropathol Appl Neurobiol. 2021 Jul 27.doi: 10.1111/nan.12756. Online ahead of print.

Astrocytes-derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein

Journal: 

Journal of Extracellular Vescicles

Date: 

12 July, 2021

J Extracell Vesicles. 2021 Jul;10(9):e12114. doi: 10.1002/jev2.12114. Epub 2021 Jul 12.

Tackling prion diseases: a review of the patent landscape

Journal: 

Expert Opinion on Therapeutic Patents

Date: 

17 June, 2021

Expert Opin Ther Pat. 2021 Jun 17. doi: 10.1080/13543776.2021.1945033

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

Journal: 

Antioxidants

Date: 

1 June, 2021

Antioxidants (Basel). 2021 Jun 1;10(6):893. doi: 10.3390/antiox10060893.

PMCA generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

Journal: 

Elife

Date: 

14 April, 2021

Elife. 2021 Apr 14;10:e65311.doi: 10.7554/eLife.65311.

Site-specific analysis of N-glycans from different sheep prion strains

Journal: 

Plos Pathogens

Date: 

18 February, 2021
PLoS Pathog. 2021 Feb 18;17(2):e1009232.doi: 10.1371/journal.ppat.1009232. eCollection 2021 Feb

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases

Journal: 

Prion

Date: 

19 December, 2020
Prion 2020 Dec;14(1):257-270.doi: 10.1080/19336896.2020.1854034.

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

Journal: 

Brain Communications

Date: 

14 September, 2020

Brain Commun. 2020 Sep 14;2(2):fcaa142. doi: 10.1093/braincomms/fcaa142. eCollection 2020.

Novel Regulators of PrP C Expression as Potential Therapeutic Targets in Prion Diseases

Journal: 

Expert Opinion on Therapeutic Targets

Date: 

7 July, 2020

Expert Opin Ther Targets. 2020 Jul 7;1-18. doi: 10.1080/14728222.2020.1782384.

The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells

Journal: 

Journal of Neurochemistry

Date: 

11 May, 2020

J Neurochem. 2020 May 11. doi: 10.1111/jnc.15040.

Chronic alpha-synuclein accumulation in rat hippocampus induces Lewy Bodies formation and specific cognitive impairments

Journal: 

eNeuro

Date: 

11 May, 2020

eNeuro. 2020 May 11. pii: ENEURO.0009-20.2020. doi: 10.1523/ENEURO.0009-20.2020

In Silico/in Vitro Screening and Hit Evaluation Identified New Phenothiazine Anti-Prion Derivati

Journal: 

European Journal of Medicinal Chemistry

Date: 

8 April, 2020

Eur J Med Chem. 2020 Apr 8;196:112295. doi: 10.1016/j.ejmech.2020.112295.

How would defining Parkinson's as a prion disease impact the search of a cure?

Journal: 

Expert Review of Neurotherapeutics

Date: 

7 April, 2020

Expert Rev Neurother. 2020 Apr 7. doi: 10.1080/14737175.2020.1753504

NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation

Journal: 

Cellular and Molecular Neurobiology

Date: 

1 April, 2020

Cell Mol Neurobiol. 2020 Apr 1. doi: 10.1007/s10571-020-00834-1.

Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface

Journal: 

International Journal of Biological Macromolecules

Date: 

14 March, 2020

Int J Biol Macromol. 2020 Mar 14. pii: S0141-8130(20)30438-4. doi: 10.1016/j.ijbiomac.2020.03.118.

Iron-mediated interaction of alpha synuclein with lipid raft model membranes

Journal: 

Nanoscale

Date: 

27 February, 2020

Nanoscale. 2020 Feb 27. doi: 10.1039/d0nr00287a.

Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain

Journal: 

Biophysical Journal

Date: 

3 January, 2020

Biophys J. 2020 Jan 3. pii: S0006-3495(19)34425-X. doi: 10.1016/j.bpj.2019.12.025. [Epub ahead of print]

Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

Journal: 

Plos Pathogens

Date: 

9 December, 2019

PLoS Pathog. 2019 Dec 9;15(12):e1008139. doi: 10.1371/journal.ppat.1008139. [Epub ahead of print]

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids

Journal: 

Scientific Reports

Date: 

9 December, 2019

Sci Rep. 2019 Dec 9;9(1):18595. doi: 10.1038/s41598-019-55078-x.

Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease

Journal: 

ACS Omega

Date: 

15 November, 2019

ACS Omega. 2019 Nov 15;4(22):19913-19924. doi: 10.1021/acsomega.9b02824. eCollection 2019 Nov 26.

Depicting Conformational Ensembles of α-Synuclein by Single Molecule Force Spectroscopy and Native Mass Spectroscopy

Journal: 

International Journal of International Science

Date: 

19 October, 2019

Int J Mol Sci. 2019 Oct 19;20(20). pii: E5181. doi: 10.3390/ijms20205181.

α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies

Journal: 

Annals of Clinica and Translational Neurology

Date: 

10 October, 2019

Ann Clin Transl Neurol. 2019 Oct;6(10):2120-2126. doi: 10.1002/acn3.50897. Epub 2019 Oct 10.

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson's disease and multiple system atrophy

Journal: 

Translational Neurodegeneration

Date: 

8 August, 2019

Transl Neurodegener. 2019 Aug 8;8:24. doi: 10.1186/s40035-019-0164-x. eCollection 2019.

Pages

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