Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Novel Regulators of PrP C Expression as Potential Therapeutic Targets in Prion Diseases

Journal: 

Expert Opinion on Therapeutic Targets

Date: 

7 July, 2020

Expert Opin Ther Targets. 2020 Jul 7;1-18. doi: 10.1080/14728222.2020.1782384.

In Silico/in Vitro Screening and Hit Evaluation Identified New Phenothiazine Anti-Prion Derivati

Journal: 

European Journal of Medicinal Chemistry

Date: 

8 April, 2020

Eur J Med Chem. 2020 Apr 8;196:112295. doi: 10.1016/j.ejmech.2020.112295.

How would defining Parkinson's as a prion disease impact the search of a cure?

Journal: 

Expert Review of Neurotherapeutics

Date: 

7 April, 2020

Expert Rev Neurother. 2020 Apr 7. doi: 10.1080/14737175.2020.1753504

NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation

Journal: 

Cellular and Molecular Neurobiology

Date: 

1 April, 2020

Cell Mol Neurobiol. 2020 Apr 1. doi: 10.1007/s10571-020-00834-1.

Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface

Journal: 

International Journal of Biological Macromolecules

Date: 

14 March, 2020

Int J Biol Macromol. 2020 Mar 14. pii: S0141-8130(20)30438-4. doi: 10.1016/j.ijbiomac.2020.03.118.

Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain

Journal: 

Biophysical Journal

Date: 

3 January, 2020

Biophys J. 2020 Jan 3. pii: S0006-3495(19)34425-X. doi: 10.1016/j.bpj.2019.12.025. [Epub ahead of print]

Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease

Journal: 

ACS Omega

Date: 

15 November, 2019

ACS Omega. 2019 Nov 15;4(22):19913-19924. doi: 10.1021/acsomega.9b02824. eCollection 2019 Nov 26.

α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies

Journal: 

Annals of Clinica and Translational Neurology

Date: 

10 October, 2019

Ann Clin Transl Neurol. 2019 Oct;6(10):2120-2126. doi: 10.1002/acn3.50897. Epub 2019 Oct 10.

Structural Consequences of Copper Binding to the Prion Protein

Journal: 

Cells

Date: 

25 July, 2019

Cells. 2019 Jul 25;8(8). pii: E770. doi: 10.3390/cells8080770.

Novel screening approaches for human prion diseases drug discovery.

Journal: 

Expert Opinion on Drug Discovery

Date: 

4 July, 2019

Expert Opin Drug Discov. 2019 Jul 4:1-11. doi: 10.1080/17460441.2019.1637851. [Epub ahead of print]

Prion Efficiently Replicates in α-Synuclein Knockout Mice

Journal: 

Molecular Neurobiology

Date: 

30 April, 2019

Mol Neurobiol. 2019 Apr 30. doi: 10.1007/s12035-019-1602-6. [Epub ahead of print]

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

Journal: 

Journal of Biological Chemistry

Date: 

12 February, 2019

J Biol Chem. 2019 Feb 12. pii: jbc.RA118.001907. doi: 10.1074/jbc.RA118.001907. [Epub ahead of print]

Copper Binding Regulates Cellular Prion Protein Function

Journal: 

Molecular Neurobiology

Date: 

7 February, 2019

Mol Neurobiol. 2019 Feb 7. doi: 10.1007/s12035-019-1510-9. [Epub ahead of print]

Brain aging: A Ianus-faced player between health and neurodegeneration

Journal: 

Journal of Neuroscience Research

Date: 

11 January, 2019

J Neurosci Res. 2019 Jan 11. doi: 10.1002/jnr.24379.

Synthetic Prion Selection and Adaptation

Journal: 

Molecular Neurobiology

Date: 

3 August, 2018

Mol Neurobiol. 2018 Aug 3. doi: 10.1007/s12035-018-1279-2. [Epub ahead of print]

Conformational properties of intrinsically disordered proteins bound to the surface of silica nanoparticles

Journal: 

Biochimica et Biophysica Acta (BBA) - General Subjects

Date: 

11 July, 2018

Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1556-1564. doi: 10.1016/j.bbagen.2018.03.026. Epub 2018 Apr 2.

Conformational properties of intrinsically disordered proteins bound to the surface of silica nanoparticles

Journal: 

Biochimica et Biophysica Acta

Date: 

2 April, 2018

Biochim Biophys Acta. 2018 Apr 2. pii: S0304-4165(18)30088-6. doi: 10.1016/j.bbagen.2018.03.026.

Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases

Journal: 

Prion

Date: 

4 March, 2018

Prion. 2018 Mar 4;12(2):127-137. doi: 10.1080/19336896.2018.1464367. Epub 2018 May 18.

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