Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

PMCA generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

Journal: 

Elife

Date: 

14 April, 2021

Elife. 2021 Apr 14;10:e65311.doi: 10.7554/eLife.65311.

Site-specific analysis of N-glycans from different sheep prion strains

Journal: 

Plos Pathogens

Date: 

18 February, 2021
PLoS Pathog. 2021 Feb 18;17(2):e1009232.doi: 10.1371/journal.ppat.1009232. eCollection 2021 Feb

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases

Journal: 

Prion

Date: 

19 December, 2020
Prion 2020 Dec;14(1):257-270.doi: 10.1080/19336896.2020.1854034.

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

Journal: 

Brain Communications

Date: 

14 September, 2020

Brain Commun. 2020 Sep 14;2(2):fcaa142. doi: 10.1093/braincomms/fcaa142. eCollection 2020.

Novel Regulators of PrP C Expression as Potential Therapeutic Targets in Prion Diseases

Journal: 

Expert Opinion on Therapeutic Targets

Date: 

7 July, 2020

Expert Opin Ther Targets. 2020 Jul 7;1-18. doi: 10.1080/14728222.2020.1782384.

The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells

Journal: 

Journal of Neurochemistry

Date: 

11 May, 2020

J Neurochem. 2020 May 11. doi: 10.1111/jnc.15040.

Chronic alpha-synuclein accumulation in rat hippocampus induces Lewy Bodies formation and specific cognitive impairments

Journal: 

eNeuro

Date: 

11 May, 2020

eNeuro. 2020 May 11. pii: ENEURO.0009-20.2020. doi: 10.1523/ENEURO.0009-20.2020

In Silico/in Vitro Screening and Hit Evaluation Identified New Phenothiazine Anti-Prion Derivati

Journal: 

European Journal of Medicinal Chemistry

Date: 

8 April, 2020

Eur J Med Chem. 2020 Apr 8;196:112295. doi: 10.1016/j.ejmech.2020.112295.

How would defining Parkinson's as a prion disease impact the search of a cure?

Journal: 

Expert Review of Neurotherapeutics

Date: 

7 April, 2020

Expert Rev Neurother. 2020 Apr 7. doi: 10.1080/14737175.2020.1753504

NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation

Journal: 

Cellular and Molecular Neurobiology

Date: 

1 April, 2020

Cell Mol Neurobiol. 2020 Apr 1. doi: 10.1007/s10571-020-00834-1.

Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface

Journal: 

International Journal of Biological Macromolecules

Date: 

14 March, 2020

Int J Biol Macromol. 2020 Mar 14. pii: S0141-8130(20)30438-4. doi: 10.1016/j.ijbiomac.2020.03.118.

Iron-mediated interaction of alpha synuclein with lipid raft model membranes

Journal: 

Nanoscale

Date: 

27 February, 2020

Nanoscale. 2020 Feb 27. doi: 10.1039/d0nr00287a.

Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain

Journal: 

Biophysical Journal

Date: 

3 January, 2020

Biophys J. 2020 Jan 3. pii: S0006-3495(19)34425-X. doi: 10.1016/j.bpj.2019.12.025. [Epub ahead of print]

Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

Journal: 

Plos Pathogens

Date: 

9 December, 2019

PLoS Pathog. 2019 Dec 9;15(12):e1008139. doi: 10.1371/journal.ppat.1008139. [Epub ahead of print]

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids

Journal: 

Scientific Reports

Date: 

9 December, 2019

Sci Rep. 2019 Dec 9;9(1):18595. doi: 10.1038/s41598-019-55078-x.

Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease

Journal: 

ACS Omega

Date: 

15 November, 2019

ACS Omega. 2019 Nov 15;4(22):19913-19924. doi: 10.1021/acsomega.9b02824. eCollection 2019 Nov 26.

Depicting Conformational Ensembles of α-Synuclein by Single Molecule Force Spectroscopy and Native Mass Spectroscopy

Journal: 

International Journal of International Science

Date: 

19 October, 2019

Int J Mol Sci. 2019 Oct 19;20(20). pii: E5181. doi: 10.3390/ijms20205181.

α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies

Journal: 

Annals of Clinica and Translational Neurology

Date: 

10 October, 2019

Ann Clin Transl Neurol. 2019 Oct;6(10):2120-2126. doi: 10.1002/acn3.50897. Epub 2019 Oct 10.

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson's disease and multiple system atrophy

Journal: 

Translational Neurodegeneration

Date: 

8 August, 2019

Transl Neurodegener. 2019 Aug 8;8:24. doi: 10.1186/s40035-019-0164-x. eCollection 2019.

Structural Consequences of Copper Binding to the Prion Protein

Journal: 

Cells

Date: 

25 July, 2019

Cells. 2019 Jul 25;8(8). pii: E770. doi: 10.3390/cells8080770.

Novel screening approaches for human prion diseases drug discovery.

Journal: 

Expert Opinion on Drug Discovery

Date: 

4 July, 2019

Expert Opin Drug Discov. 2019 Jul 4:1-11. doi: 10.1080/17460441.2019.1637851. [Epub ahead of print]

Prion Efficiently Replicates in α-Synuclein Knockout Mice

Journal: 

Molecular Neurobiology

Date: 

30 April, 2019

Mol Neurobiol. 2019 Apr 30. doi: 10.1007/s12035-019-1602-6. [Epub ahead of print]

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration

Journal: 

Viruses

Date: 

14 March, 2019

Viruses. 2019 Mar 14;11(3). pii: E261. doi: 10.3390/v11030261.

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

Journal: 

Journal of Biological Chemistry

Date: 

12 February, 2019

J Biol Chem. 2019 Feb 12. pii: jbc.RA118.001907. doi: 10.1074/jbc.RA118.001907. [Epub ahead of print]

Copper Binding Regulates Cellular Prion Protein Function

Journal: 

Molecular Neurobiology

Date: 

7 February, 2019

Mol Neurobiol. 2019 Feb 7. doi: 10.1007/s12035-019-1510-9. [Epub ahead of print]

Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases

Journal: 

Molecular Neurobiology

Date: 

1 February, 2019

Mol Neurobiol. 2019 Feb 1. doi: 10.1007/s12035-019-1505-6.

Brain aging: A Ianus-faced player between health and neurodegeneration

Journal: 

Journal of Neuroscience Research

Date: 

11 January, 2019

J Neurosci Res. 2019 Jan 11. doi: 10.1002/jnr.24379.

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene

Journal: 

Acta Neuropathologica Communications

Date: 

3 January, 2019

Acta Neuropathol Commun. 2019 Jan 3;7(1):1. doi: 10.1186/s40478-018-0656-4.

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

Journal: 

Journal of Medicinal Chemistry

Date: 

24 August, 2018

J Med Chem. 2018 Sep 13;61(17):7640-7656. doi: 10.1021/acs.jmedchem.8b00610. Epub 2018 Aug 24.

Synthetic Prion Selection and Adaptation

Journal: 

Molecular Neurobiology

Date: 

3 August, 2018

Mol Neurobiol. 2018 Aug 3. doi: 10.1007/s12035-018-1279-2. [Epub ahead of print]

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