Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Conformational properties of intrinsically disordered proteins bound to the surface of silica nanoparticles

Journal: 

Biochimica et Biophysica Acta

Date: 

2 April, 2018

Biochim Biophys Acta. 2018 Apr 2. pii: S0304-4165(18)30088-6. doi: 10.1016/j.bbagen.2018.03.026.

Hemoglobin mRNA Changes in the Frontal Cortex of Patients with Neurodegenerative Diseases

Journal: 

Frontiers Neuroscience

Date: 

22 January, 2018

Front Neurosci. 2018 Jan 22;12:8. doi: 10.3389/fnins.2018.00008. eCollection 2018.

The Role Of The Prion Protein In The Internalization Of α-Synuclein Amyloids

Journal: 

Prion

Date: 

8 January, 2018

Prion. 2018 Jan 8:0. doi: 10.1080/19336896.2017.1423186. [Epub ahead of print]

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations.

Journal: 

Acta Neuropathologica

Date: 

4 January, 2018

Acta Neuropathol. 2018 Jan 4. doi: 10.1007/s00401-017-1803-x. [Epub ahead of print]

The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein

Journal: 

Plos One

Date: 

21 November, 2017

PLoS One. 2017 Nov 21;12(11):e0188308. doi: 10.1371/journal.pone.0188308. eCollection 2017.

Differential overexpression of SERPINA3 in human prion diseases

Journal: 

Scientific Reports

Date: 

15 November, 2017

Sci Rep. 2017 Nov 15;7(1):15637. doi: 10.1038/s41598-017-15778-8.

Elucidating the function of the prion protein

Journal: 

Plos Pathogens

Date: 

31 August, 2017

PLos Pathog. 2017 Aug 31;13(8):e1006458. doi: 10.1371/journal.ppat.1006458. eCollection 2017 Aug.

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

Journal: 

Scientific Reports

Date: 

30 August, 2017

Sci Rep. 2017 Aug 30;7(1):10050. doi: 10.1038/s41598-017-10236-x

Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia

Journal: 

Scientific Reports

Date: 

7 April, 2017

Sci Rep. 2017 Apr 7;7:46269. doi: 10.1038/srep46269

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases

Journal: 

European Journal of Medicinal Chemistry

Date: 

1 November, 2016

Eur J Med Chem. 2016 Nov 1. pii: S0223-5234(16)30935-7. doi: 10.1016/j.ejmech.2016.10.064. [Epub ahead of print]

Characterization of prion protein function by focal neurite stimulation

Journal: 

Journal of Cell Science

Date: 

15 October, 2016

J Cell Sci. 2016 Oct 15;129(20):3878-3891. Epub 2016 Sep 2.

 

The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain

Journal: 

Journal of Biological Chemistry

Date: 

14 October, 2016

J Biol Chem. 2016 Oct 14;291(42):21857-21868. Epub 2016 Aug 17.

In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution

Journal: 

Frontiers in Neuroscience

Date: 

27 September, 2016

Front Neurosci. 2016 Sep 27;10:437. eCollection 2016.

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

Journal: 

Analytical Chemistry

Date: 

6 September, 2016

Anal Chem. 2016 Sep 6;88(17):8468-75. doi: 10.1021/acs.analchem.6b00731. Epub 2016 Aug 12.

The Priority position paper: Protecting Europe's food chain from prions

Journal: 

Prion

Date: 

3 May, 2016

Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801.

Whole Blood gene expression profiling in preclinical and clinical cattle infected with atypical bovine spongiform encephalopathy

Journal: 

PLoS One

Date: 

13 April, 2016

PLoS One. 2016 Apr 13;11(4):e0153425. doi: 10.1371/journal.pone.0153425. eCollection 2016.

A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers

Journal: 

Biotechniques

Date: 

1 January, 2016

Biotechniques. 2016 Jan 1;60(1):35-41. doi: 10.2144/000114371. eCollection 2016.

Synthetic prions with novel strain-specified properties.

Journal: 

PLOS Pathogen

Date: 

31 December, 2015

PLoS Pathog. 2015 Dec 31;11(12):e1005354. doi: 10.1371/journal.ppat.1005354. eCollection 2015.

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.

Journal: 

Scientific Reports

Date: 

20 October, 2015

Sci Rep. 2015 Oct 20;5:15253. doi: 10.1038/srep15253.

Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains

Journal: 

Scientific Reports

Date: 

9 July, 2015

Sci Rep. 2015 Jul 9;5:11971. doi: 10.1038/srep11971.

Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c)

Journal: 

PeerJ

Date: 

19 March, 2015

PeerJ. 2015 Mar 19;3:e811. doi: 10.7717/peerj.811. eCollection 2015.

New insights into structural determinants of prion protein folding and stability

Journal: 

Prion

Date: 

4 March, 2015

Prion. 2015 Mar 4;9(2):119-24. doi: 10.1080/19336896.2015.1022023.

Approaches for discovering anti-prion compounds: lessons learned and challenges ahead

Journal: 

Expert Opinion on Drug Discovery

Date: 

15 February, 2015

Expert Opin Drug Discov. 2015 Apr;10(4):389-97. doi: 10.1517/17460441.2015.1016498. Epub 2015 Feb 15

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation

Journal: 

Antioxidants & Redox Signaling

Date: 

4 February, 2015

Antioxid Redox Signal. 2015 Mar 20;22(9):772-84. doi: 10.1089/ars.2014.6032. Epub 2015 Feb 4.

Structural determinants in prion protein folding and stability

Journal: 

Journal of Molecular Biology

Date: 

11 November, 2014

J Mol Biol. 2014 Nov 11;426(22):3796-810. doi: 10.1016/j.jmb.2014.09.017. Epub 2014 Oct 2.

Synthetic prions and other human neurodegenerative proteinopathies

Journal: 

Virus Research

Date: 

31 October, 2014

Virus Res. 2014 Oct 31. pii: S0168-1702(14)00437-7. doi: 10.1016/j.virusres.2014.10.020.

Prion protein-specific antibodies-development, modes of action and therapeutics application

Journal: 

Viruses

Date: 

1 October, 2014

Viruses. 2014 Oct 1;6(10):3719-37. doi: 10.3390/v6103719.

Prion protein and aging

Journal: 

Frontiers in Cell and Developmental Biology

Date: 

29 August, 2014

Front Cell Dev Biol. 2014 Aug 29;2:44. doi: 10.3389/fcell.2014.00044. eCollection 2014. Review.

Progress towards structural understanding of infectious sheep PrP-amyloid

Journal: 

Prion

Date: 

5 August, 2014

Prion. 2014;8(5):344-58. doi: 10.4161/19336896.2014.983754.

Prion protein interaction with soil humic substances: environmental implications

Journal: 

PLoS ONE

Date: 

17 June, 2014

PLoS One. 2014 Jun 17;9(6):e100016. doi: 10.1371/journal.pone.0100016. eCollection 2014.

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