Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Prion receptors, prion internalization, intra- and inter-cellular transport

Journal: 

Progress in Molecular Biology and Translational Science

Date: 

20 February, 2023
2023;196:15-41. doi: 10.1016/bs.pmbts.2022.06.022. Epub 2022 Jul 13

Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models

Journal: 

European Journal of Medicinal Chemistry

Date: 

5 January, 2023
2023 Jan 5;245(Pt 1):114923. doi: 10.1016/j.ejmech.2022.114923. Epub 2022 Nov 15.

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins

Journal: 

Prion

Date: 

3 January, 2023
2023 Dec;17(1):1-6. doi: 10.1080/19336896.2022.2163835.

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins

Journal: 

Prion

Date: 

17 December, 2022
2023 Dec;17(1):1-6. doi: 10.1080/19336896.2022.2163835

Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein

Journal: 

Cell Death & Disease

Date: 

16 December, 2022
2022 Dec 16;13(12):1048. doi: 10.1038/s41419-022-05489-y

Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein

Journal: 

Cell Death & Disease

Date: 

16 December, 2022
2022 Dec 16;13(12):1048. doi: 10.1038/s41419-022-05489-y.

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease

Journal: 

ACS Chemical Neuroscience

Date: 

7 December, 2022
2022 Dec 7;13(23):3314-3329. doi: 10.1021/acschemneuro.2c00357. Epub 2022 Nov 29.

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease

Journal: 

ACS Chemical Neuroscience

Date: 

7 December, 2022
2022 Dec 7;13(23):3314-3329. doi: 10.1021/acschemneuro.2c00357. Epub 2022 Nov 29.

Gerstmann-Sträussler-Scheinker Disease with F198S Mutation Induces Independent Tau and Prion Protein Pathologies in Bank Voles

Journal: 

Biomolecules

Date: 

21 October, 2022
2022 Oct 21;12(10):1537. doi: 10.3390/biom12101537.

Recent advances in cellular models for discovering prion disease therapeutics

Journal: 

Expert Opinion on Drug Discovery

Date: 

17 September, 2022
2022 Sep;17(9):985-996. doi: 10.1080/17460441.2022.2113773. Epub 2022 Aug 24

Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Journal: 

Biology (Basel)

Date: 

16 September, 2022
2022 Sep 16;11(9):1358. doi: 10.3390/biology11091358

Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein

Journal: 

Chemical Science

Date: 

5 August, 2022
2022 Aug 5;13(35):10406-10427. doi: 10.1039/d2sc00345g. eCollection 2022 Sep 14.

Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance

Journal: 

Journal of medicinal chemistry

Date: 

14 July, 2022
J Med Chem 2022 Jul 14;65(13):8998-9010. doi: 10.1021/acs.jmedchem.2c00205. Epub 2022 Jun 30.

Serpin Signatures in Prion and Alzheimer's Diseases

Journal: 

Molecular Neurobiology

Date: 

13 April, 2022
Mol Neurobiology. 2022 Apr 13. doi: 10.1007/s12035-022-02817-3. Online ahead of print.

PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt-Jakob Disease

Journal: 

Frontiers in Aging Neuroscience

Date: 

25 March, 2022

Front Aging Neurosci. 2022 Mar 25;14:848991. doi: 10.3389/fnagi.2022.848991. eCollection 2022.

The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures

Journal: 

Molecular Neurobiology

Date: 

9 January, 2022

Mol Neurobiol. 2022 Jan 9. doi: 10.1007/s12035-021-02666-6

Therapeutic strategies for identifying small molecules against prion diseases

Journal: 

Cell and Tissue Research

Date: 

6 January, 2022

Cell Tissue Res. 2022 Jan 6. doi: 10.1007/s00441-021-03573-x.

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

Journal: 

Cells

Date: 

28 December, 2021
Cells. 2021 Dec 28;11(1):87. doi: 10.3390/cells11010087.

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

Journal: 

Molecular Neurodegeneration

Date: 

11 December, 2021

Mol Neurodegener. 2021 Dec 11;16(1):82.doi: 10.1186/s13024-021-00491-y.

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

Journal: 

Viruses

Date: 

17 August, 2021

Viruses. 2021 Aug 17;13(8):1625. doi: 10.3390/v13081625.

Expression pattern of Perilipins in human brain during aging and in Alzheimer's Disease

Journal: 

Neuropathology Applied Neurobiology

Date: 

27 July, 2021

Neuropathol Appl Neurobiol. 2021 Jul 27.doi: 10.1111/nan.12756. Online ahead of print.

Astrocytes-derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein

Journal: 

Journal of Extracellular Vescicles

Date: 

12 July, 2021

J Extracell Vesicles. 2021 Jul;10(9):e12114. doi: 10.1002/jev2.12114. Epub 2021 Jul 12.

Tackling prion diseases: a review of the patent landscape

Journal: 

Expert Opinion on Therapeutic Patents

Date: 

17 June, 2021

Expert Opin Ther Pat. 2021 Jun 17. doi: 10.1080/13543776.2021.1945033

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

Journal: 

Antioxidants

Date: 

1 June, 2021

Antioxidants (Basel). 2021 Jun 1;10(6):893. doi: 10.3390/antiox10060893.

PMCA generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

Journal: 

Elife

Date: 

14 April, 2021

Elife. 2021 Apr 14;10:e65311.doi: 10.7554/eLife.65311.

Site-specific analysis of N-glycans from different sheep prion strains

Journal: 

Plos Pathogens

Date: 

18 February, 2021
PLoS Pathog. 2021 Feb 18;17(2):e1009232.doi: 10.1371/journal.ppat.1009232. eCollection 2021 Feb

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases

Journal: 

Prion

Date: 

19 December, 2020
Prion 2020 Dec;14(1):257-270.doi: 10.1080/19336896.2020.1854034.

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

Journal: 

Brain Communications

Date: 

14 September, 2020

Brain Commun. 2020 Sep 14;2(2):fcaa142. doi: 10.1093/braincomms/fcaa142. eCollection 2020.

Novel Regulators of PrP C Expression as Potential Therapeutic Targets in Prion Diseases

Journal: 

Expert Opinion on Therapeutic Targets

Date: 

7 July, 2020

Expert Opin Ther Targets. 2020 Jul 7;1-18. doi: 10.1080/14728222.2020.1782384.

The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells

Journal: 

Journal of Neurochemistry

Date: 

11 May, 2020

J Neurochem. 2020 May 11. doi: 10.1111/jnc.15040.

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