Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Expression pattern of Perilipins in human brain during aging and in Alzheimer's Disease

Journal: 

Neuropathology Applied Neurobiology

Date: 

27 July, 2021

Neuropathol Appl Neurobiol. 2021 Jul 27.doi: 10.1111/nan.12756. Online ahead of print.

Astrocytes-derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein

Journal: 

Journal of Extracellular Vescicles

Date: 

12 July, 2021

J Extracell Vesicles. 2021 Jul;10(9):e12114. doi: 10.1002/jev2.12114. Epub 2021 Jul 12.

Tackling prion diseases: a review of the patent landscape

Journal: 

Expert Opin Ther Pat

Date: 

17 June, 2021

Expert Opin Ther Pat. 2021 Jun 17. doi: 10.1080/13543776.2021.1945033

Site-specific analysis of N-glycans from different sheep prion strains

Journal: 

Plos Pathogens

Date: 

18 February, 2021
PLoS Pathog. 2021 Feb 18;17(2):e1009232.doi: 10.1371/journal.ppat.1009232. eCollection 2021 Feb

Novel Regulators of PrP C Expression as Potential Therapeutic Targets in Prion Diseases

Journal: 

Expert Opinion on Therapeutic Targets

Date: 

7 July, 2020

Expert Opin Ther Targets. 2020 Jul 7;1-18. doi: 10.1080/14728222.2020.1782384.

In Silico/in Vitro Screening and Hit Evaluation Identified New Phenothiazine Anti-Prion Derivati

Journal: 

European Journal of Medicinal Chemistry

Date: 

8 April, 2020

Eur J Med Chem. 2020 Apr 8;196:112295. doi: 10.1016/j.ejmech.2020.112295.

How would defining Parkinson's as a prion disease impact the search of a cure?

Journal: 

Expert Review of Neurotherapeutics

Date: 

7 April, 2020

Expert Rev Neurother. 2020 Apr 7. doi: 10.1080/14737175.2020.1753504

NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation

Journal: 

Cellular and Molecular Neurobiology

Date: 

1 April, 2020

Cell Mol Neurobiol. 2020 Apr 1. doi: 10.1007/s10571-020-00834-1.

Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface

Journal: 

International Journal of Biological Macromolecules

Date: 

14 March, 2020

Int J Biol Macromol. 2020 Mar 14. pii: S0141-8130(20)30438-4. doi: 10.1016/j.ijbiomac.2020.03.118.

Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain

Journal: 

Biophysical Journal

Date: 

3 January, 2020

Biophys J. 2020 Jan 3. pii: S0006-3495(19)34425-X. doi: 10.1016/j.bpj.2019.12.025. [Epub ahead of print]

Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease

Journal: 

ACS Omega

Date: 

15 November, 2019

ACS Omega. 2019 Nov 15;4(22):19913-19924. doi: 10.1021/acsomega.9b02824. eCollection 2019 Nov 26.

α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies

Journal: 

Annals of Clinica and Translational Neurology

Date: 

10 October, 2019

Ann Clin Transl Neurol. 2019 Oct;6(10):2120-2126. doi: 10.1002/acn3.50897. Epub 2019 Oct 10.

Structural Consequences of Copper Binding to the Prion Protein

Journal: 

Cells

Date: 

25 July, 2019

Cells. 2019 Jul 25;8(8). pii: E770. doi: 10.3390/cells8080770.

Novel screening approaches for human prion diseases drug discovery.

Journal: 

Expert Opinion on Drug Discovery

Date: 

4 July, 2019

Expert Opin Drug Discov. 2019 Jul 4:1-11. doi: 10.1080/17460441.2019.1637851. [Epub ahead of print]

Prion Efficiently Replicates in α-Synuclein Knockout Mice

Journal: 

Molecular Neurobiology

Date: 

30 April, 2019

Mol Neurobiol. 2019 Apr 30. doi: 10.1007/s12035-019-1602-6. [Epub ahead of print]

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

Journal: 

Journal of Biological Chemistry

Date: 

12 February, 2019

J Biol Chem. 2019 Feb 12. pii: jbc.RA118.001907. doi: 10.1074/jbc.RA118.001907. [Epub ahead of print]

Copper Binding Regulates Cellular Prion Protein Function

Journal: 

Molecular Neurobiology

Date: 

7 February, 2019

Mol Neurobiol. 2019 Feb 7. doi: 10.1007/s12035-019-1510-9. [Epub ahead of print]

Pages