Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein

Journal: 

Plos One

Date: 

21 November, 2017

PLoS One. 2017 Nov 21;12(11):e0188308. doi: 10.1371/journal.pone.0188308. eCollection 2017.

Differential overexpression of SERPINA3 in human prion diseases

Journal: 

Scientific Reports

Date: 

15 November, 2017

Sci Rep. 2017 Nov 15;7(1):15637. doi: 10.1038/s41598-017-15778-8.

Elucidating the function of the prion protein

Journal: 

Plos Pathogens

Date: 

31 August, 2017

PLos Pathog. 2017 Aug 31;13(8):e1006458. doi: 10.1371/journal.ppat.1006458. eCollection 2017 Aug.

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

Journal: 

Scientific Reports

Date: 

30 August, 2017

Sci Rep. 2017 Aug 30;7(1):10050. doi: 10.1038/s41598-017-10236-x

Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia

Journal: 

Scientific Reports

Date: 

7 April, 2017

Sci Rep. 2017 Apr 7;7:46269. doi: 10.1038/srep46269

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases

Journal: 

European Journal of Medicinal Chemistry

Date: 

1 November, 2016

Eur J Med Chem. 2016 Nov 1. pii: S0223-5234(16)30935-7. doi: 10.1016/j.ejmech.2016.10.064. [Epub ahead of print]

Characterization of prion protein function by focal neurite stimulation

Journal: 

Journal of Cell Science

Date: 

15 October, 2016

J Cell Sci. 2016 Oct 15;129(20):3878-3891. Epub 2016 Sep 2.

 

The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain

Journal: 

Journal of Biological Chemistry

Date: 

14 October, 2016

J Biol Chem. 2016 Oct 14;291(42):21857-21868. Epub 2016 Aug 17.

In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution

Journal: 

Frontiers in Neuroscience

Date: 

27 September, 2016

Front Neurosci. 2016 Sep 27;10:437. eCollection 2016.

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

Journal: 

Analytical Chemistry

Date: 

6 September, 2016

Anal Chem. 2016 Sep 6;88(17):8468-75. doi: 10.1021/acs.analchem.6b00731. Epub 2016 Aug 12.

The Priority position paper: Protecting Europe's food chain from prions

Journal: 

Prion

Date: 

3 May, 2016

Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801.

Whole Blood gene expression profiling in preclinical and clinical cattle infected with atypical bovine spongiform encephalopathy

Journal: 

PLoS One

Date: 

13 April, 2016

PLoS One. 2016 Apr 13;11(4):e0153425. doi: 10.1371/journal.pone.0153425. eCollection 2016.

A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers

Journal: 

Biotechniques

Date: 

1 January, 2016

Biotechniques. 2016 Jan 1;60(1):35-41. doi: 10.2144/000114371. eCollection 2016.

Synthetic prions with novel strain-specified properties.

Journal: 

PLOS Pathogen

Date: 

31 December, 2015

PLoS Pathog. 2015 Dec 31;11(12):e1005354. doi: 10.1371/journal.ppat.1005354. eCollection 2015.

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.

Journal: 

Scientific Reports

Date: 

20 October, 2015

Sci Rep. 2015 Oct 20;5:15253. doi: 10.1038/srep15253.

Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains

Journal: 

Scientific Reports

Date: 

9 July, 2015

Sci Rep. 2015 Jul 9;5:11971. doi: 10.1038/srep11971.

Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c)

Journal: 

PeerJ

Date: 

19 March, 2015

PeerJ. 2015 Mar 19;3:e811. doi: 10.7717/peerj.811. eCollection 2015.

New insights into structural determinants of prion protein folding and stability

Journal: 

Prion

Date: 

4 March, 2015

Prion. 2015 Mar 4;9(2):119-24. doi: 10.1080/19336896.2015.1022023.

Approaches for discovering anti-prion compounds: lessons learned and challenges ahead

Journal: 

Expert Opinion on Drug Discovery

Date: 

15 February, 2015

Expert Opin Drug Discov. 2015 Apr;10(4):389-97. doi: 10.1517/17460441.2015.1016498. Epub 2015 Feb 15

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation

Journal: 

Antioxidants & Redox Signaling

Date: 

4 February, 2015

Antioxid Redox Signal. 2015 Mar 20;22(9):772-84. doi: 10.1089/ars.2014.6032. Epub 2015 Feb 4.

Structural determinants in prion protein folding and stability

Journal: 

Journal of Molecular Biology

Date: 

11 November, 2014

J Mol Biol. 2014 Nov 11;426(22):3796-810. doi: 10.1016/j.jmb.2014.09.017. Epub 2014 Oct 2.

Synthetic prions and other human neurodegenerative proteinopathies

Journal: 

Virus Research

Date: 

31 October, 2014

Virus Res. 2014 Oct 31. pii: S0168-1702(14)00437-7. doi: 10.1016/j.virusres.2014.10.020.

Prion protein-specific antibodies-development, modes of action and therapeutics application

Journal: 

Viruses

Date: 

1 October, 2014

Viruses. 2014 Oct 1;6(10):3719-37. doi: 10.3390/v6103719.

Prion protein and aging

Journal: 

Frontiers in Cell and Developmental Biology

Date: 

29 August, 2014

Front Cell Dev Biol. 2014 Aug 29;2:44. doi: 10.3389/fcell.2014.00044. eCollection 2014. Review.

Progress towards structural understanding of infectious sheep PrP-amyloid

Journal: 

Prion

Date: 

5 August, 2014

Prion. 2014;8(5):344-58. doi: 10.4161/19336896.2014.983754.

Prion protein interaction with soil humic substances: environmental implications

Journal: 

PLoS ONE

Date: 

17 June, 2014

PLoS One. 2014 Jun 17;9(6):e100016. doi: 10.1371/journal.pone.0100016. eCollection 2014.

Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques

Journal: 

BMC Genomics

Date: 

5 June, 2014

BMC Genomics. 2014 Jun 5;15:434. doi: 10.1186/1471-2164-15-434.

Defined α-synuclein prion-like molecular assemblies spreading in cell culture

Journal: 

BMC Neuroscience

Date: 

4 June, 2014

BMC Neurosci. 2014 Jun 4;15:69. doi: 10.1186/1471-2202-15-69.

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody

Journal: 

Journal of the American Chemical Society

Date: 

22 January, 2014

J Am Chem Soc. 2014 Jan 22;136(3):937-44. doi: 10.1021/ja407527p. Epub 2014 Jan 8.

SAXS structural study of PrPSc reveals ~11 nm diameter of basic double intertwined fibers

Journal: 

Prion

Date: 

18 November, 2013

Prion. 2013 Nov 18

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