Prion Protein
Project Areas
The team
The Laboratory

Giuseppe Legname

The main focus of his research program is the physiological function of the prion protein in mammals and the mechanisms of prion replication as well as the structural characterization of molecular determinants for prion infectivity.

What are Prion Diseases?

Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of rare, incurable neurodegenerative disorders leading to motor and cognitive impairments, extensive brain damage and neuronal degeneration.


Our laboratory works on the cutting edge to understand Prion diseases from many different angles.

The focus of the Laboratory of Prion Biology is studying prion diseases, rare and fatal neurodegenerative maladies that affect humans and animals for which there currently is no diagnostic tool, nor cure.

Latest News

Functional and Structural Genomics PhD Call

Functional and Structural Genomics PhD Spring Call is now open!

Deadline for online submission of applications: 21 April, 2020

Nosing around α-synuclein

Science Translational Medicine, 28 Aug 2019

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