Publications

Publications

For links to abstracts, full text articles and publications by the Legname Laboratory and related resources, please visit PubMed: a service of the National Library of Medicine and the National Institutes of Health.

Legname laboratory publications and related resources

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases

Journal: 

European Journal of Medicinal Chemistry

Date: 

1 November, 2016

Eur J Med Chem. 2016 Nov 1. pii: S0223-5234(16)30935-7. doi: 10.1016/j.ejmech.2016.10.064. [Epub ahead of print]

Characterization of prion protein function by focal neurite stimulation

Journal: 

Journal of Cell Science

Date: 

15 October, 2016

J Cell Sci. 2016 Oct 15;129(20):3878-3891. Epub 2016 Sep 2.

 

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

Journal: 

Analytical Chemistry

Date: 

6 September, 2016

Anal Chem. 2016 Sep 6;88(17):8468-75. doi: 10.1021/acs.analchem.6b00731. Epub 2016 Aug 12.

Synthetic prions with novel strain-specified properties.

Journal: 

PLOS Pathogen

Date: 

31 December, 2015

PLoS Pathog. 2015 Dec 31;11(12):e1005354. doi: 10.1371/journal.ppat.1005354. eCollection 2015.

Approaches for discovering anti-prion compounds: lessons learned and challenges ahead

Journal: 

Expert Opinion on Drug Discovery

Date: 

15 February, 2015

Expert Opin Drug Discov. 2015 Apr;10(4):389-97. doi: 10.1517/17460441.2015.1016498. Epub 2015 Feb 15

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation

Journal: 

Antioxidants & Redox Signaling

Date: 

4 February, 2015

Antioxid Redox Signal. 2015 Mar 20;22(9):772-84. doi: 10.1089/ars.2014.6032. Epub 2015 Feb 4.

Structural determinants in prion protein folding and stability

Journal: 

Journal of Molecular Biology

Date: 

11 November, 2014

J Mol Biol. 2014 Nov 11;426(22):3796-810. doi: 10.1016/j.jmb.2014.09.017. Epub 2014 Oct 2.

Synthetic prions and other human neurodegenerative proteinopathies

Journal: 

Virus Research

Date: 

31 October, 2014

Virus Res. 2014 Oct 31. pii: S0168-1702(14)00437-7. doi: 10.1016/j.virusres.2014.10.020.

Prion protein and aging

Journal: 

Frontiers in Cell and Developmental Biology

Date: 

29 August, 2014

Front Cell Dev Biol. 2014 Aug 29;2:44. doi: 10.3389/fcell.2014.00044. eCollection 2014. Review.

Prion protein interaction with soil humic substances: environmental implications

Journal: 

PLoS ONE

Date: 

17 June, 2014

PLoS One. 2014 Jun 17;9(6):e100016. doi: 10.1371/journal.pone.0100016. eCollection 2014.

Spontaneous generation of anchorless prions in transgenic mice.

Journal: 

PNAS

Date: 

27 December, 2011

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21223-8. Epub 2011 Dec 12.

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